Optimal Therapeutic Intervention Timepoints for siRNA-Based Huntington's Disease Therapies
Optimal Therapeutic Intervention Timepoints for siRNA-Based Huntington's Disease Therapies
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Online Event
Date
Description
Creative Biolabs has invited Dr. Markita Landry to walk us through how her team developed a near Infrared Catecholamine nanosensor (nIRCat) and used real-time imaging to find out what drives late-disease decreases in evoked dopamine release, and how to use these findings as optimal therapeutic intervention timepoints for siRNA-based HD therapies.
During this webinar, we will discuss the following key points:
* The development of nIRCat that can be used to image "hot spots" of dopamine activity in the striatum of R6/2 HD model mice
* How to use the findings as optimal therapeutic intervention timepoints for siRNA-based HD therapies
* How dopaminergic projections are affected by mutant huntingtin, and whether specific targeting of these loci is important for developing gene therapy efforts
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Optimal Therapeutic Intervention Timepoints for siRNA-Based Huntington's Disease Therapies
From Free